Poster Gallery

Abstract Application
The related main theme: A. Stroke and Cerebral vascular disorders

THE DIFFERENCES BETWEEN SENSITIVITY, SPECIFICITY, ACCURACY OF NEUTROPHYL LYMPHOCYCTE RATIO, LYMPHOCYTE MONOCYTE RATIO, HIGH SENSITIVITY C REACTIVE PROTEIN AS OUTCOME PREDICTOR IN ACUTE ISCHEMIC STROKE

Authers:

Heru  Pranata, MD 1 , Aldy Safruddin Rambe, PhD, MD 2 , Chairil Amin Batubara, MD 3 , 
1 Resident of Neurology Department, Faculty of Medicine Universitas Sumatera Utara/ Adam Malik General Hospital, Medan
2 Professor of Neurology Department, Faculty of Medicine Universitas Sumatera Utara/ Adam Malik General Hospital, Medan
3 Staff of Neurology Department, Faculty of Medicine Universitas Sumatera Utara/ Adam Malik General Hospital, Medan
Corresponding Author:

Heru  Pranata

keywords: High Sensitivity C Reactive Protein, Outcome, Lymphocycte Monocycte Ratio, Neutrophil Lymphocyte Ratio, Ischemic Stroke
Abstract for original article

OBJECTIVES /BACKGROUND:
Inflammation plays a role in the pathophysiology of cerebral ischemia. Inflammation involves disruption of the blood-brain barrier, leukocyte infiltrations, endothelial cell activation, accumulation of oxidants, and inflammatory mediators which can develop rapidly and can cause secondary injury to brain tissues.

MATERIAL and METHOD:
This study used a cross-sectional design. Sampling was done at Haji Adam Malik General Hospital Medan and taken as many as 38 subjects. Neutrophils, lymphocytes, monocytes, and high sensitivity c reactive protein were examined on the first day of admission. The outcome was assessed by using a modified Rankin scale on the fourteenth day of admission. Sensitivity, specificity, and accuracy were assessed, and then a z-score table was used to assess the differences.

RESULT:
Demographic characteristics of the subjects are; average age is 62 years old, the highest educational level is high school graduate, and the most occupation is unemployed. The sensitivity, specificity and accuracy of neutrophyl lymphocyte ratio (NLR) were 84%, 89%, 86%; lymphocyte monocyte ratio (LMR) were 76%, 85%, 81% and high sensitivity c reactive protein (hsCRP) were 89%, 89%, 89%. The z scores from sensitivity difference between NLR and hsCRP were 1.1 (p=0.8); LMR and hsCRP 2.1 (p=0.9); NLR and LMR 1.3 (p=0.9). The z scores from specificity difference between NLR and hsCRP were 0.0 (p=0.5); LMR and hsCRP 0.8 (p=0.7); NLR and LMR 0.8 (p=0.7). The z scores from accuracy difference between NLR and hsCRP were 0.6 (p=0.6); LMR and hsCRP 1.3 (0.9); NLR and LMR 0.8 (p=0.7) in predicting acute ischemic stroke outcome.

DISCUSSION:
There are no significant differences in sensitivity, specificity, and accuracy of NLR, LMR, and hsCRP in predicting acute ischemic stroke outcomes.


Back